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Pope expresses solidarity with tornado survivors

VATICAN CITY (AP) ? Pope Francis has expressed his "closeness to the families of all who died in the Oklahoma tornado," with special concern for "those who lost young children."

The pope posted a Twitter message to the survivors Tuesday, and followed up with a telegram to the archbishop of Oklahoma City, Paul S. Coakley.

The deadly tornado struck a suburb of Oklahoma City on Monday, destroying homes and an elementary school, and many of the victims were children.

In the telegram, Francis said he remains "conscious of the tragic loss of life and the immensity of the work of rebuilding that lies ahead." The pontiff conveyed to the community "assurance of his solidarity and closeness in prayer."

Source: http://news.yahoo.com/pope-expresses-solidarity-tornado-survivors-165306023.html

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Am. Samoa to keep flier miles for govt travelers

PAGO PAGO, American Samoa (AP) ? American Samoa plans to take away frequent flier miles from government workers who travel on behalf of the U.S. territory.

Gov. Lolo Matalasi Moliga says the territory will use the miles to help medical patients travel off-island when needed, or help students travel for educational programs.

Moliga says Hawaiian Airlines agreed to the plan that takes effect June 1. Hawaiian is the only carrier connecting the U.S. territory to the rest of the country.

Moliga announced the policy this week in a memo to the government's various agencies. He acknowledges some may see the policy as unfair but says it is morally wrong for employees to get extra benefits from traveling for the territory.

American Samoa budgeted nearly $6 million for government travel in fiscal 2013.

Source: http://news.yahoo.com/am-samoa-keep-flier-miles-govt-travelers-195557586.html

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Paris Hilton Joins Lil Wayne's Cash Money Family?

Heiress says she's signed to Weezy's label and will focus on house music on her summer sophomore album.
By Jocelyn Vena


Paris Hilton
Photo: Jason Merritt/ Getty Images

Source: http://www.mtv.com/news/articles/1707867/paris-hilton-signs-to-cash-money-lil-wayne.jhtml

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Oklahoma tornado: How to find people, pets - U.S. News

Google

Google's Crisis Response Center provides information and compiles resources to aid tornado survivors and their loved ones.

By Rosa Golijan

In the aftermath of one of the deadliest tornadoes in U.S. history, many are desperately trying to reach loved ones in areas affected by the disastrous event. Google and the Red Cross are helping confirm the safety of tornado survivors, while the Oklahoma Humane Society and Reddit users band together to take care of missing pets.

Google Crisis Response Center and Person Finder
Google has set up?a?Crisis Response Center page?on which it provides shelter information, weather reports, public alerts and links to a variety of resources to aid those in or around the towns of Moore, Newcastle and southern portions of Oklahoma City. The search giant has also?enabled the Google Person Finder tool at a plain and simple-to-use site for sharing and gathering information about those missing after the tornado. The tool was originally created after the 2010 Haiti earthquake.

As with previous versions of the tool, all someone needs to do is enter as much of a person's name as he or she knows and Google will provide any related information ? including last known location, physical descriptions, last reported status and messages left by those searching for the individual.

Those seeking to add information to the database will need to provide the full name of the individual they've got information about, as well as their own names and e-mail addresses.

The American Red Cross' 'Safe and Well'
The American Red Cross' "Safe and Well" page?is also serving as a way to confirm that loved ones are doing all right. It functions similarly to the Google Person Finder, but instead focuses on individuals listing themselves as "safe and well," in addition to letting others search for loved ones.

Oklahoma Humane Society
Efforts are being made to ensure that pets make their ways home safely as well.?The Oklahoma Humane Society is doing its best to house and treat lost and injured animals.?The organization's Development Office, which is collecting donations for a disaster relief fund, can be reached at (405) 607-8991.

Reddit
Reddit users are banding together to keep track of lost and found pets?in the town of Moore. Photos of, and information about, lost and found animals is easily searchable on the site.

Facebook
A Facebook page, May 19th 2013 OK Tornado Doc & Picture Recovery, is helping unite photos and documents scattered by the tornado with survivors.?

Related:

Want more tech news or interesting links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook posts, or circling her on?Google+.

Source: http://usnews.nbcnews.com/_news/2013/05/21/18400373-oklahoma-tornado-how-to-find-people-pets

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Hands-on with the Otterbox Defender and Commuter cases for the Samsung Galaxy S 4

Otterbox S4

Otterbox is here in Vegas at CTIA 2013 with its Defender and Commuter series cases for the Samsung Galaxy S4

CTIA is always a hotbed for the latest and greatest accessories and this year's show is no different -- Otterbox was onsite tonight at the Showstoppers kickoff event in Las Vegas' Venetian Hotel with both its Defender and Commuter cases for the Samsung Galaxy S 4. Otterboxes probably aren't the most attractive cases you can buy for your shiny new S4, and they certainly aren't the sleekest, but they provide the ultra-protection you've come to expect from the company. Both the Commuter and Defender series come in a slew of color options and they're both available now for $34.95 and $49.95 respectively. A quick video, and some more shots can be found in the gallery after the break.

read more

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/okdxQvOn25E/story01.htm

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MU researchers develop radioactive nanoparticles that target cancer cells

MU researchers develop radioactive nanoparticles that target cancer cells [ Back to EurekAlert! ] Public release date: 21-May-2013
[ | E-mail | Share Share ]

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia

This is an early step toward developing therapies for metastasized cancers, MU scientist says

COLUMBIA, Mo. Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive cancers.

"Depending on the type of cancer, primary tumors usually are not the cause of death for cancer patients," Lewis said. "If a cancer metastasizes, or spreads creating hard-to-find tumors, it often becomes fatal. Having a way to identify and shrink these secondary tumors is of utmost importance when fighting to save people with these diseases."

In an effort to find a way to locate and kill secondary tumors, Lewis, in collaboration with J. David Robertson, director of research at the MU Research Reactor and professor of chemistry in the College of Arts and Science, have successfully created nanoparticles made of a radioactive form of the element lutetium. The MU scientists then covered the lutetium nanoparticles with gold shells and attached targeting agents.

In previous research, Lewis has already proven the effectiveness of similar targeting agents in mice and dogs suffering from tumors. In that research, the targeting agents were attached to single radioactive atoms that were introduced into the bodies of animals with cancer. The targeting agents were able to seek out the tumors existing within the animals, which were then revealed through radio-imaging of those animals.

In their current research, the MU scientists have shown the targeting agents can deliver the new radioactive lutetium nanoparticles to lymphoma tumor cells without attaching to and damaging healthy cells in the process. Robertson says this is an important step toward developing therapies for lymphoma and other advanced-stage cancers.

"The ability to deliver multiple radioactive atoms to individual cancer cells should greatly increase our ability to selectively kill these cells," Robertson said. "We are very optimistic about the synergy of combining the targeting strategy developed in Dr. Lewis's lab with our work on new radioactive nanoparticles."

Lewis has been invited to present his research at the City of Hope National Medical Center this June in Duarte, Calif.

This study is an example of the collaborative research taking place in the One Health, One Medicine area of Mizzou Advantage. The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, the researchers will request permission from the federal government to begin human drug development. After this status has been granted, Lewis and Robertson may conduct human clinical trials with the hope of developing new treatments.

Lewis also is a principal investigator in the Research Service at the Harry S. Truman Memorial Veterans' Hospital. This research was supported by awards from the National Cancer Institute and the Department of Veterans Affairs as well as resources made available by Department of Veterans Affairs through use of facilities at the Harry S. Truman Memorial Veterans' Hospital in Columbia, Mo.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


MU researchers develop radioactive nanoparticles that target cancer cells [ Back to EurekAlert! ] Public release date: 21-May-2013
[ | E-mail | Share Share ]

Contact: Nathan Hurst
hurstn@missouri.edu
573-882-6217
University of Missouri-Columbia

This is an early step toward developing therapies for metastasized cancers, MU scientist says

COLUMBIA, Mo. Cancers of all types become most deadly when they metastasize and spread tumors throughout the body. Once cancer has reached this stage, it becomes very difficult for doctors to locate and treat the numerous tumors that can develop. Now, researchers at the University of Missouri have found a way to create radioactive nanoparticles that target lymphoma tumor cells wherever they may be in the body. Michael Lewis, an associate professor of oncology in the MU College of Veterinary Medicine, says being able to target secondary tumors is vital to successfully treating patients with progressive cancers.

"Depending on the type of cancer, primary tumors usually are not the cause of death for cancer patients," Lewis said. "If a cancer metastasizes, or spreads creating hard-to-find tumors, it often becomes fatal. Having a way to identify and shrink these secondary tumors is of utmost importance when fighting to save people with these diseases."

In an effort to find a way to locate and kill secondary tumors, Lewis, in collaboration with J. David Robertson, director of research at the MU Research Reactor and professor of chemistry in the College of Arts and Science, have successfully created nanoparticles made of a radioactive form of the element lutetium. The MU scientists then covered the lutetium nanoparticles with gold shells and attached targeting agents.

In previous research, Lewis has already proven the effectiveness of similar targeting agents in mice and dogs suffering from tumors. In that research, the targeting agents were attached to single radioactive atoms that were introduced into the bodies of animals with cancer. The targeting agents were able to seek out the tumors existing within the animals, which were then revealed through radio-imaging of those animals.

In their current research, the MU scientists have shown the targeting agents can deliver the new radioactive lutetium nanoparticles to lymphoma tumor cells without attaching to and damaging healthy cells in the process. Robertson says this is an important step toward developing therapies for lymphoma and other advanced-stage cancers.

"The ability to deliver multiple radioactive atoms to individual cancer cells should greatly increase our ability to selectively kill these cells," Robertson said. "We are very optimistic about the synergy of combining the targeting strategy developed in Dr. Lewis's lab with our work on new radioactive nanoparticles."

Lewis has been invited to present his research at the City of Hope National Medical Center this June in Duarte, Calif.

This study is an example of the collaborative research taking place in the One Health, One Medicine area of Mizzou Advantage. The early-stage results of this research are promising. If additional studies, including animal studies, are successful within the next few years, the researchers will request permission from the federal government to begin human drug development. After this status has been granted, Lewis and Robertson may conduct human clinical trials with the hope of developing new treatments.

Lewis also is a principal investigator in the Research Service at the Harry S. Truman Memorial Veterans' Hospital. This research was supported by awards from the National Cancer Institute and the Department of Veterans Affairs as well as resources made available by Department of Veterans Affairs through use of facilities at the Harry S. Truman Memorial Veterans' Hospital in Columbia, Mo.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/uom-mrd052113.php

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The digital design imperative | Feature | Computer Arts magazine

Opinions matter. And mine has always been that if bad typography and Photoshop work don?t make your blood boil then you shouldn?t be a designer. If you can sit on the train opposite an ad featuring poorly kerned letters or view a Frankenstein?s monster comp of a ?lead character when young? movie prop photo and not twitch, you are creatively dead inside.

Slink away now if you?re unmoved by either example, or hang around and get motivated. The role of designer has changed beyond all recognition since I left college (it?s moved fast; I?m not that old). So what is graphic design? Well, before ?digital? it used to be relatively easy to define: branding, brochures, editorial layouts, posters, flyers and packaging, for starters.

That list still exists, but many brochures are now interactive, from PDFs to eBooks with websites that either replicate or deliver the same content. Great editorial layouts are still essential for tablet-based magazines and eBooks because the eye is arrested by the skilful juxtaposition of stunning images and intelligent typography. Posters, meanwhile, work on various levels, from the 48-sheet variety now on many digital Jumbotrons to our ever-increasing desktop screen sizes offering the scale previously reserved for printed posters. And flyers, unless they come from a local pizza delivery business, are now emails, Facebook posts or Tweets. We haven?t lost packaging from our high streets yet, but the online marketplace offers increasing numbers of virtually packaged downloads.

So, who gives a crap? Things change. Technology advances and forces us to move with it. It?s a take that can lead to the kind of sloppy Photoshop, branding and layouts that make me want to punch inanimate objects (or designers). It?s an attitude cultivated by creatives who don?t live and breathe design, as well as clients who believe our computers do all the work.

So snap out of it. And appreciate the incredible opportunities to not only design great visual experiences, but also to bring them to life as incredible user experiences. The graphic design label has been well and truly scrapped ? welcome to the wonderful new world of design, where the brief to create postage stamps becomes the task to build instantly recognisable icons or miniaturised album covers and book jackets, where the fight to be seen and remembered provides the ultimate pixel-pushing challenge. Wearable technology and smart TVs will provide your next playgrounds, so start thinking about future opportunities to make a design difference.

Knock down the mental barriers and apply great design thinking to everything you do. Don?t assign different standards to different work or clients ? we live in a world in which a local butcher can have as much global visibility as Wal-Mart. The world?s eyes are on your kerning, your cut-outs and your colour palette.
?

Discover 10 amazing examples of experimental design at our sister site, Creative Bloq.

Source: http://www.computerarts.co.uk/features/digital-design-imperative

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Online Dating: Find Your FaceMate Matches Mates By Facial Features

Divorc?es may be looking for love in all the wrong places.

Online dating site Find Your FaceMate sets out to match prospective mates based on similar facial features, which, according to site founder Christina Bloom, is a good sign of compatibility.

"I believe that people are attracted to people with similar facial features," Bloom said in an interview with IBTimes TV (see above).

According to the site, scientists' findings "prove that passion is subconsciously ignited when we spot someone whose facial features are similar to our own."

"When we fall in love (or meet our facial feature match) the neurological response in the brain triggers a release of endorphins and other mood enhancing chemicals that puts being in love in a category all on its own," the site continues.

But does the science work? Kerri Johnson, an assistant psychology professor at UCLA, told Good Morning America that "there is evidence that general liking improves when people look like you," but that the research points to pairs that have similar levels of attractiveness, and not necessarily similar facial features.

In other words, the jury is out!

Watch the video above for more on this dating site, then weigh in: would you use this service to find love after divorce?

Keep in touch! Check out HuffPost Divorce on Facebook and Twitter.

Related on HuffPost:

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Source: http://www.huffingtonpost.com/2013/05/19/online-dating-find-your-f_n_3295087.html

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Nokia Lumia 928 (Verizon Wireless)


If at first you don't succeed? Well, that might be a little misleading. Nokia's Lumia 920?for AT&T has been modestly successful as far as Windows phones are concerned. But Nokia is trying again with the $99.99 Lumia 928 for Verizon Wireless. It's almost the exact same phone?as the 920, except it's been fitted with a new, lighter design, and improved low-light camera performance. The Lumia 920 was arguably the best Windows phone on the market, so there's no doubt the Lumia 928 now holds the title. It's a well-priced alternative to Android and Apple, but it's still not the best phone on Verizon.

Design and Call Quality
If the Lumia 920 is flat-out humongous, then the Lumia 928 is just really big. Whereas the 920 weighs in at a whopping 6.53 ounces, the 928 is somewhat more reasonable at 5.71 ounces. That's still a lot heavier than the 4.6-ounce Samsung Galaxy S 4?which is not only lighter, but has a much bigger screen than the Lumia 928. And it's nearly two full ounces heavier than Apple's 4-ounce iPhone 5, though that phone has a smaller screen. But there's no way around it?the Lumia 928 is a big phone. At 5.24 by 2.71 by 0.44 inches (HWD), you can still hold and operate it with just one hand, but there's a lot of excess bezel around the display at every angle.

Nokia has traded the matte polycarbonate of the Lumia 920 for a high-gloss finish. I miss the matte, which has a much more sumptuous, luxe feel. But I especially miss all of the fun colors, like red, blue, and yellow. The Lumia 928 is only available in black or white.

The rolled edges of the 920 have been replaced with much sharper angles?you can even stand the 928 up vertically if you choose to do so. The headphone jack is at the top left of the phone, while the micro USB jack is next to it in the center. On the right side you'll find Volume, Power, and Camera buttons. I would've preferred the buttons be broken up differently, as I kept pressing the Volume button when I meant to press Power. There's no memory card slot, and the 2,000mAh battery is sealed in. I got 9 hours and 32 minutes of talk time, which is very close to what we saw on the Lumia 920, which has the same battery. Also like the 920, the 928 has features wireless charging, but you need to purchase a separate (wired) charging pad in order to use it.

The Lumia 920's 4.5-inch IPS LCD has been replaced by a 4.5-inch OLED panel. It has the same 1,280-by-768-pixel resolution, and the same 334-pixels-per-inch screen density. The main difference is that OLED looks even richer, though I don't dig the PenTile pixel layout, which can cause text and images to appear fuzzy if you look closely. But the phone is much more readable outside than many of its competitors.

The Lumia 928 supports a ton of frequency bands, so you can connect to global HSPA+ and LTE networks if Verizon has roaming agreements with those carriers. The phone also has 802.11 a/b/g/n Wi-Fi on the 2.4GHz and faster 5GHz bands, along with Bluetooth 3.0, GPS, and NFC. Reception was decent and 4G LTE data speeds in Manhattan were on par with what we've been seeing lately.

This is a great phone if you like to talk. Incoming calls get very loud and sound clear, with a real richness and warmth. The same goes for calls made with the phone, which were easy to hear even when made from an area with lots of construction noise in the background. The speakerphone is borderline loud enough to hear outside, and calls sounded great over a Jawbone Era?Bluetooth headset. I had no trouble triggering Microsoft's voice command software, which works fine for making calls, but is no match for Apple's Siri.

Windows Phone 8 and Apps
The Lumia 928 uses the same 1.5GHz dual-core Qualcomm Snapdragon S4 Plus MSM8960 processor as the 920, not to mention the Lumia 822, the HTC 8X, and the Samsung Ativ Odyssey. In short, there isn't much variation among any of the Windows phones. That's mostly thanks to Microsoft, which runs a much tighter ship with Windows Phone than Google does with its open-source Android. That's good for quality assurance, but bad for innovation. Either way, benchmark scores on this phone were on par with other WP8 devices.

Windows Phone 8 is a quick, minimalist operating system built around a series of live tiles on your home screen. The tiles continuously pull information from social networks, the Internet, messages, and local content stored on your phone, which is both useful and fun. Of particular note is the People Hub,?which pulls together your contacts from different sources?like email, Facebook, and Twitter?and presents you with all of your social-networking updates in one place.?It's more flexible than Apple's iOS, but less than Google's Android. For a closer look at WP8, you can read our?full review.

The biggest difference among Windows phones lies in the included apps, which is where Nokia once had a leg up on the competition. When the Lumia 920 came out, most of Nokia's proprietary apps were exclusive to Nokia Phones. Now Nokia is serving up those apps for all WP8 phones in the Windows Phone store, though they come preloaded on the 928. Nokia is doing this in order to acquire more user-generated data for a better overall experience, though it claims the apps themselves work best on Lumia devices.

(Next page: Camera and Conclusions)

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/3M87NdYfsFI/0,2817,2418988,00.asp

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Obama to address Morehouse College commencement

WASHINGTON (AP) ? President Barack Obama is delivering the commencement address at Morehouse College, the historically black, all-male institution that counts Martin Luther King Jr. among its alumni.

The Atlanta-based private school says about 500 students will receive undergraduate degrees Sunday, becoming what are known as "Morehouse Men."

It is Obama's second graduation speech of the year. Last Sunday, he urged graduates of Ohio State University in Columbus to become vigorous participants in their democracy.

After the speech, Obama is scheduled to attend a Democratic Senate fundraiser in Atlanta.

Obama's third and final commencement address of the season comes Friday at the U.S. Naval Academy in Annapolis, Md.

Source: http://news.yahoo.com/obama-address-morehouse-college-commencement-083541960.html

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Several Tips to Enable Make your Mortgage loan Home finance loan ...

Another one of the best places to obtain assistance with motorcycle financing is always to check around the internet. This push is a part of a cover-up of the items really went wrong and does absolutely not even attempt to address the main problem that led to this financial and economic collapse. Some people have been ill-advised and possess used short-term loans to hide a lot of the money they owe or overspending. If the loan is just not repaid, the borrower typically renew it for another a fortnight by paying of the fee an extra time. The Project on Student Debt notes the typical debt for college kids at public universities is all about $20,000, but grows to between $27,650 and $33,050 for college kids at private schools.

Though this can be quite useful in permitting you fill with your budget, they're often followed by extremely high rates of interest. Fax Fast Canadian Payday Loans Faxing replicates of physical papers is necessary by some creditors, nevertheless, you more than likely tend not to use a fax equipment. The banks will likely then be instructed to use the funds raised to provide cheaper loans to small , medium-sized businesses. The funds obtained with fast payday loans allow you to take care of your many short term financial purposes. In addition, the trio of prospects the Blue Jays did end up getting for Hallday weren't even that impressive at time instant payday loans that deal required wells to provide $2 billion worth of loan modifications to have an estimated 14,900 homeowners starting this season. Coming up which has a budget to pay for your loans is, of course, a function of considering your earnings and realistically cutting your expenses to depart more income for your repayments.

Step 3: Enter simply how much you'd probably like to pay for being a down payment on your own car purchase. As the repayment is inherently linked to your next payday, then there ought to be no reasons why an automated transfer should fail. So, never absence out to get this accommodation today. A great provider really should deal with you correctly although you may possess a bad credit standing also as the bit distressed financially. Occupy Wall Street: Complaints Include Rising Student Loan Debt, Insurance Costs. Besides that, it will also be easier to enable them to collect your payment at the end of your respective coming payday.

Source: http://www.nuhitz.com/blog/40085/several-tips-to-enable-make-your-mortgage-loan-home-finance-loan-authorized/

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Annandale VA: Police investigating solicitors in Annandale community

As a result of several complaints from residents of the Ravensworth-Bristow community in Annandale about door-to-door solicitors, officers from the West Springfield Police District have issued warnings to several unlicensed solicitors and told to leave them the neighborhood.

Those solicitors are associated with these companies: Power Home Remodeling (based in Chester, Pa.),?
E Enterprises Inc. (Lutherville, Md.), the Smart Circle International LLC (Plano, Texas), Fast Trak Management (Falls Church, VA).

When one resident asked to see a solicitor?s license when someone from Power Home Remodeling knocked on this door, the man ignored him and went to the house next door. The resident thought the solicitors might be connected with a series of day-time burglaries that have plagued the neighborhood.

He later learned that Power Home Remodeling sends dozens of young adults with criminal records and outstanding warrants into a? neighborhood and that the Fairfax County Police Department is investigating the company. Another resident was alerted by her dog that there might have been a solicitor lurking in her backyard and she was concerned that he was could have been casing the house for a burglary.

If salespeople or home improvement representatives come to your door, the police suggests asking to see a solicitor?s license. If they don?t have one, or you see suspicious activity in your neighborhood, call the police non-emergency number, 703/691-2131.

In addition to the possibility of break-ins, there are plenty of unscrupulous people out there trying to con the elderly into overpriced yard work or home improvements. The police refer to those scammers as ?woodchucks,?? and the Mason Police commander, Capt. Carol Wilhite, has made cracking down on them one of her top priorities.

Source: http://annandaleva.blogspot.com/2013/05/police-investigating-solicitors-in.html

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Newer diabetes medications may have additional cardiovascular benefits

May 17, 2013 ? A newer class of medications used to control blood sugar levels in type 2 diabetics may also improve cardiovascular health, researchers from The Ohio State University Wexner Medical Center reported in a new meta-analysis presented yesterday at the American Society of Hypertension's Annual Scientific Meeting and Exposition.

Researchers found that the use of glucagon-like peptide-1 agonists, known as GLP-1 mimetics, resulted in a systolic blood pressure (SBP) reduction of -2.22 mmHg, a loss of almost six pounds, and a decrease of HbA1c -- an indicator of blood sugar levels -- of 0.41 percent.

"While our findings must be viewed as preliminary it does provide compelling evidence of potential long-term cardiovascular advantages of GLP-1 analogs," said lead investigator Sanjay Rajagopalan, MD, John W. Wolfe Professor of Cardiovascular Medicine and director for vascular research at Ohio State's Wexner Medical Center. "Stroke and heart disease are the leading causes of death in people with diabetes, so this is an area that deserves additional study."

For the meta-analysis, the researchers analyzed 33 randomized studies involving 12,469 patients with type 2 diabetes assessing the glycemic control efficacy of both short acting and long acting GLP-1 mimetics. They specifically looked at GLP-1 impact on sitting systolic blood pressure, diastolic blood pressure, weight, HbA1c and heart rate after 12-56 weeks of treatment. All studies included a comparator group that used other anti-glycemic medications or placebo.

"The significance of our meta-analysis is that it uses direct evidence from both published and unpublished trials that include blood pressure data and glycemic efficacy of GLP-1 agonists with a non-incretin control group including placebo," noted Rajagopalan. "The results were maintained when the placebo controlled trials alone were examined."

The research team also found that the baseline body weight, HbA1c, SBP, study duration, weight loss, HbA1c reduction or heart rate change did not predict the size of the estimated treatment effect or explain heterogeneity between studies.

GLP-1 is a peptide hormone that stimulates insulin and inhibits glucagon secretion in a glucose-dependent manner. Recent studies suggest that the GLP-1 receptor is widely expressed in the cardiovascular system with a variety of effects including improvements in endothelial function that may lead to lowering of blood pressure. GLP-1 mimetics are available globally for the treatment of type 2 diabetes.

Type 2 diabetes is a common form of diabetes mellitus that develops especially in adults and most often in obese individuals. It is characterized by hyperglycemia resulting from impaired insulin utilization coupled with the body's inability to compensate with increased insulin production. Diabetes affects an estimated 23.6 million people in the US (90 percent to 95 percent have type 2 diabetes) -- 17.9 million have been diagnosed, but 5.7 million are unaware they have the disease. According to the most recent statistics, diabetes was the sixth leading cause of death, and the fifth leading cause of death from disease in 2007. Diabetes costs $116 billion annually in direct medical costs and $58 billion annually in indirect costs (loss of work, disability, loss of life).

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/0GOb63kwhd0/130517085058.htm

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Jamie Krauss Hess: The 5 Biggest Changes You'll Find in Fire Island Pines This Summer

It's that time of year again: time to buff up, bare all and hit the beach. Any good gay knows that Fire Island, specifically the Pines region, is one of the most beautiful, historic and hedonistic summer destinations in the world. You may also know that the Pines had it rough over the past couple of years. A devastating fire leveled the beloved Pavilion nightclub in 2011, and Hurricane Sandy took its toll in 2012. But much like the resilient population that inhabits its shores, the Pines won't be quieted. In the face of adversity, it rises up stronger than before. And how could it not? This year marks the Pines' 60th anniversary. Here are five things that will make summer 2013 in the Pines the best one ever... and why you'll want to be there to experience it.

  • The Pavilion

    Like a phoenix rising from the ashes, so goes the Pavilion. Finally rebuilt after the fire that demolished it two years ago, the space was reimagined by the acclaimed design firm Hollwich Kushner (HWKN). The resurrected venue includes a first-floor Welcome Bar and a second floor that boasts a 2,760-square-foot terrace outside and a 2,000-square-foot dance floor inside. "We designed the new Pavilion around the Fire Island community," says Matthias Hollwich, co-founder of HWKN. "The building forms intimate spaces out of a single volume." Hollwich adds, "Aside from designing a building with personality, our primary focus was to recreate the social engine that was so unique to the famed Pavilion of the '90s."

  • Reclaiming The Beat

    Legendary New York promoter Tony Fornabaio has signed on as Entertainment Director, promising to bring back the true "sound of the Pines." Once known for its cutting-edge music, the Pines was the birthplace of a unique set of sexy, sultry sounds -- a special brand of beachy house and nuevo disco. "We're looking to recapture the unique sound the island used to have," explains Fornabaio. "Musically, the island has moved away from what it used to be. It's become reliant on pop music. While there is nothing wrong with pop, it is our intention to bring back that memorable, soulful sound that Fire Island is known for." Just what does this mean? Take a look at the opening-weekend lineup. With disco legends like Robbie Leslie and Michael Fierman commanding the DJ booth, the dance floor is sure to be awash in that sexy Fire Island vibe. Nostalgia not your thing? Don't worry. Eddie Elias and Tony Moran are on hand Saturday night to deliver their special brand of beats, treats and hard-hitting circuit sounds. <em>(Photo courtesy of the <a href="https://www.facebook.com/pages/The-Fire-Island-Pines-historical-preservation-society/102245773168899" target="_blank">Fire Island Pines Historical Preservation Society</a>)</em>

  • Art And Programming

    Let's face it: Sometimes the Pines gets a bad rap. People think it's all about partying, hot guys and... <em>ahem</em>... you know what. True, the Pines vacationer traditionally likes to get his drink on, and there's nothing wrong with a little cruising during High Tea. But this summer, the Pines will up the cultural ante with an elevated roster of interesting, innovative programming and an infusion of visual and performance art. When the Pavilion is not busy pumping out beats from its state-of-the-art sound system, it will play host to variety shows (comedians, drag shows, vaudeville and burlesque), as well as the return of the popular "Boardwalk Talks" series, which, last year, offered discussions with the likes of Larry Kramer. Ben Rimalower is performing his one-man show <em>Patti Issues</em> throughout the summer, Haus of Mimosa will bring a hilarious review unlike anything you've ever seen, and the infamous Candis Cayne will be back in the Pines frequently, bringing her trademark glamor and pizazz. Art will be another main focus this summer, appearing in ways Pinesgoers have never experienced. Matthew Blesso (CEO of Blesso Properties, the managing owner of the Pines) is known for infusing art into everything he does (take a look at his Tantalo Hotel in Panama City) and has planned for a major art infusion to run throughout the commercial district. Dotting the landscape will be sculptures, murals and temporary installations curated from a global portfolio of artists. Be prepared for an exciting upgrade with this forward-thinking aesthetic. Trust us, this ain't your granddaddy's Pines experience!

  • Upgraded Hospitality Experience

    Because between all the partying, you <em>are</em> on vacation, after all! General Manager Constantino Papadakis promises a fully upgraded, unmatched hospitality experience for residents, guests and daytrip visitors alike. "Fire Island is a magical getaway for people, and we want to make sure that every person who steps off the ferry is made to feel welcome and accommodated," he explains. "Bartenders that are smiling and friendly, highly trained wait staff and a management team that helps people navigate the intricate ins and outs of the island -- this finely tuned staff will be in place, and available to our guests like never before." The food and beverage experience has changed too, with the introduction of all-new menus at the Canteen and Blue Whale that include organic and gluten-free options. The wine selection is all locally sourced from wineries in upstate New York and Long Island, and master mixologiest Sean Labbe (Top of the Standard, aka the "Boom Boom Room") will ensure that drinks at the Pool Deck, the Pavilion and the Blue Whale and the smoothies at the Muscle Bar are all over-the-top creative. As if you needed <em>another</em> reason to get tipsy.

  • Sustainability And Philanthropy

    In the midst of sunny, beachy days and wild, salacious nights, it's nice to also feel that you've done something good for humanity and the environment. The Pines has got you covered. Blesso has enacted a sustainability plan for summer 2013 that has never been attempted in the Pines. In addition to composting food for fertilizer and introducing an updated recycling program, they acquired all "green" materials for food and beverage service, including sourcing biodegradable materials for the 200,000-plus cups used for serving booze (yes, folks, that's how many drinks you go through in a summer!). Charitable efforts abound all summer long, kicked off by the Worldwide Orphans fundraiser in July, which will be hosted by Rosie O'Donnell. Papadakis is also cultivating a wide range of charitable partnerships, including the launch of the HERO program, which will offer discounts to public safety service personnel, such as members of the military, law enforcement and firefighters.

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Source: http://www.huffingtonpost.com/jamie-krauss-hess/the-5-biggest-changes-youll-find-in-fire-island-pines-this-summer_b_3295245.html

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শনিবার, ১৮ মে, ২০১৩

'Frances Ha' star Greta Gerwig is always worth watching

The scenes in 'Frances Ha' featuring Greta Gerwig and her character's best friend ring true in depicting female friendships.

By Peter Rainer,?Film critic / May 17, 2013

'Frances Ha' stars Greta Gerwig (r.) and Adam Driver (l.).

IFC/AP

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Greta Gerwig is a big, gawky actress who is also, paradoxically, quite lithe. She seems to have replaced Parker Posey as the ?It? girl of the indies. She manages to turn her klutziness into a kind of grace.

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As Frances, the dithering, knockabout, perpetually put-upon heroine of Noah Baumbach?s ?Frances Ha,? Gerwig is worth watching even when her scenes fall flat. Frances is a struggling dancer who spends much of the movie moving in and out of digs in Brooklyn and Manhattan and Westchester. She?s always on the go and yet never quite going anywhere. Even when she takes a whirlwind sojourn to Paris, she might as well be slumming in Soho.

Baumbach, who also co-wrote the script with Gerwig (his romantic partner), has a loose improvisatory feel for funky comedy. In the scenes with Frances?s best friend, Sophie (Mickey Sumner), the film seems especially true to the nature of female friendships. It?s a skimpy, overextended riff, but some of the seemingly tossed-off moments are lovely. Grade: B (Rated R for sexual references and language.)

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/68KT0uRSAAY/Frances-Ha-star-Greta-Gerwig-is-always-worth-watching

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Orb favored to take Preakness, set up Triple try

BALTIMORE (AP) ? Everything's a go for Orb.

The Kentucky Derby winner was in a playful mood the day before the Preakness, making faces for photographers between nibbles of grass outside his stall at Pimlico Race Course.

"He's really settled in well. He seems to be energetic about what he's doing so I couldn't be more pleased," trainer Shug McGaughey said on a warm and sunny Friday morning. "We're excited about giving him a whirl to see if we can get it done and go on to the next step."

Getting it done would mean defeating eight rivals in the 1 3-16-mile Preakness to set up a Triple Crown try in the Belmont Stakes three weeks from Saturday. Orb is the even-money favorite, and there's a growing feeling that this 3-year-old bay colt may be special enough to give thoroughbred racing its first Triple Crown champion since Affirmed in 1978.

"We'd sure love to have that opportunity," said McGaughey, seeming relaxed and confident. "Probably the racing world would love to see it, too. It brings a lot more attention to what we're doing from all standpoints."

Orb extended his winning streak to five with a thrilling victory in the Derby two weeks ago, when jockey Joel Rosario patiently guided the colt from 17th to first in the final half mile over a sloppy track.

In the Preakness, Orb will break from the No. 1 post, a spot that has seen only one winner ? Tabasco Cat in 1994 ? since 1961.

"Who knows how this race is going to go, but I don't think it will be a problem," Rosario said of the inside post. "He's a horse that comes from behind, so I really don't think it will affect him. I'm just excited to go into this with a horse who has a chance to win."

A chance?

While rival trainers aren't conceding the race, most agree Orb is the best of the bunch.

"Orb, he's a freak. Right now, everybody should be rooting for Orb, except for the connections of the other horses in the race," trainer Bob Baffert said ? and he's got a horse in the race, 12-1 choice Govenor Charlie. "Anybody who's not rooting for Orb, there's something mentally wrong with them."

Baffert has been there before. Three of his five Preakness winners had also won the Derby, but were unable to complete the Triple Crown with a win in the Belmont. He says the Preakness is the least stressful of the three races.

"There is absolutely no pressure, believe it or not because you've just won the Derby," he said. "You're flying high and everybody's excited. You don't think about it. The next one (the Belmont) is the pressure."

Getting to the next one may sound easy. It isn't. Six of the past eight Derby winners did not win the Preakness, and McGaughey is well aware of the pitfalls.

"There are a lot of ways you can lose. Freaky things can happen," he said. "You hope he doesn't get in any trouble, you hope he handles the track, you hope he handles the kickback of the dirt, you hope he handles the day. If he does all that, I would have to think it will take a pretty darn good horse to beat him."

Maybe it's Goldencents, who did not take to the slop at Churchill Downs and finished 17th after winning the Santa Anita Derby in April.

"Orb's not like a one-race hit. All year long he's been super impressive," said Goldencents trainer Doug O'Neill, who won the Derby and Preakness last year with I'll Have Another, only to scratch the colt the day before the Belmont because of a tendon injury. "But we've seen Goldencents do some brilliant things in the afternoon. If he does, I think he can beat him."

Maybe it's Itsmyluckyday, another top 3-year-old who did not handle the sloppy track and finished 15th in the Derby.

"He's given me every sign that he's ready for the war; he's ready for the race; he's ready for the battle," trainer Eddie Plesa Jr., said. "Let's just get it on."

Or maybe it's Departing, one of the three horses in the race who did not run in the Derby. Orb knows Departing well ? the two were pals growing up at Claiborne Farm in Paris, Ky., and ran around together in the same field. The gelding has won four of five starts, and comes into the Preakness off a win in the Illinois Derby.

And, of course, there's D. Wayne Lukas, who has three of the nine entries in Oxbow, Will Take Charge and Titletown Five, a colt owned by Green Bay Packer greats Paul Hornung and Willie Davis. Lukas, like Baffert, has five Preakness wins, and his next victory in a Triple Crown race would give him a record 14 ? one more than "Sunny Jim" Fitzsimmons.

Oxbow was sixth and Will Take Charge eighth in the Derby, while Titletown Five is a maiden winner who ran fourth in the Derby Trial.

"You have to be careful about that much emphasis on one race," Lukas said of Orb's Derby win. "You change the surface, you shorten the race, you put him in the one hole. These are things he'll have to overcome. He's the best horse. It's his race to lose. But it only takes one horse to spoil your day."

Weather could be a factor, too. The latest forecast for Saturday is calling for a 50 percent chance of rain with temperatures reaching the low 70s. Post time for the race on NBC is 6:20 p.m.

While Orb will take his shot at becoming the 34th horse with a chance at the Triple Crown ? 11 have done it, 19 failed and three others did not run in the Belmont ? several other historic milestones are in play. Rosie Napravnik will be aboard 5-1 second choice Mylute in an attempt to become the first female to the win the Preakness and Kevin Krigger, who rides Goldencents, looks to become the first black jockey to win since Willie Simms with Sly Fox in 1898.

Orb's rapid rise began with his win in the Fountain of Youth, followed by a solid victory in the Florida Derby before he ran off with the Kentucky Derby. The colt is co-owned by racing royalty ? Ogden Mills "Dinny" Phipps and his first cousin, Marylander Stuart Janney III. They run their racing operation the traditional way ? breeding and racing their own horses rather than attending sales and trying to buy champions.

McGaughey has been the Phipps' trainer for 28 years, and has campaigned such champions as Easy Goer, Inside Information and the undefeated Personal Ensign.

"This has kind of shown that with Stuart Janney's relationship with breeding that it can be done in a different way," McGaughey said. "There's a long line of pedigree that's been in their family for years and years and years and there's a lot of thought process in breeding horses to mares ? whether right or wrong. And we might have gotten a little lucky this time."

___

Follow Richard Rosenblatt on Twitter at: http://www.twitter.com/rosenblattap

Source: http://news.yahoo.com/orb-favored-preakness-set-triple-try-174610554.html

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How the Dow Jones industrial average fared

Signs of a slowing economy combined with comments from a Federal Reserve official helped pull the stock market down Thursday.

The news on the U.S. economy gave investors little to get excited about. Applications for unemployment benefits rose last week and manufacturing slowed in the mid-Atlantic region. Wal-Mart Stores sank after warning of weaker earnings ahead.

The Dow Jones industrial average fell 42.47 points, or 0.3 percent, to close at 15,233.22.

The Standard & Poor's 500 index fell 8.31 points, or 0.5 percent, to 1,650.47.

The Nasdaq composite index fell 6.37 points, or 0.2 percent, to 3,465.24.

For the week:

The Dow is up 114.73 points, or 0.8 percent.

The S&P 500 is up 16.77 points, or 1 percent.

The Nasdaq is up 28.66 points, or 0.8 percent.

For the year:

The Dow is up 2,129.08 points, or 16.2 percent.

The S&P 500 is up 224.28 points, or 15.7 percent.

The Nasdaq is up 445.73 points, or 14.8 percent.

Source: http://news.yahoo.com/dow-jones-industrial-average-fared-211711235.html

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শুক্রবার, ১৭ মে, ২০১৩

Can math models of gaming strategies be used to detect terrorism networks?

May 16, 2013 ? The answer is yes, according to a paper in the SIAM Journal on Discrete Mathematics.

In a paper published in the journal last month, authors Anthony Bonato, Dieter Mitsche, and Pawel Pralat describe a mathematical model to disrupt flow of information in a complex real-world network, such as a terrorist organization, using minimal resources.

Terror networks are comparable in their structure to hierarchical organization in companies and certain online social networks, where information flows in one direction from a source, which produces the information or data, downwards to sinks, which consume it. Such networks are called hierarchical social networks.

"In such networks, the flow of information is often one way," explains author Pawel Pralat. "For example, a celebrity such as Justin Bieber sends out a tweet, which is sent to millions of his followers. These followers send out their own retweets, and so on. We may therefore view hierarchical social networks as directed networks without cycles, or directed acyclic graphs (DAGs)."

Here, there is no requirement for reciprocity (the celebrity does not necessarily follow his or her followers). Similarly, in a terrorist network, the leaders pass plans down to the foot soldiers, and usually only one messenger needs to receive the message for the plan to be executed.

Disruption of the flow of information would correspond to halting the spread of news in an online social network or intercepting messages in a terror network.

The authors propose a generalized stochastic model for the flow and disruption of information based on a two-player outdoor game called "Seepage," where players who depict agents attempt to block the movement of another player, an intruder, from a source node to a sink. "The game -- motivated by the 1973 eruption of the Eldfell volcano in Iceland -- displays some similarities to an approach used in mathematical counterterrorism, where special kinds of DAGs are used to model the disruption of terrorist cells," says Pralat.

The motivating eruption caused a major crisis at the time, as lava flow threatened to close off the harbor, the island's main source of income. In the game, inhabitants attempt to protect the harbor by pouring water on the volcanic lava to halt its progress. A mathematical model of the game pits two opponents against each other -- the sludge, or intruder, against the greens, or agents -- forming a directed acyclic graph, with one source (the top of the volcano) and many sinks representing the lake. The parameter, "seepage," represents the amount of contamination, and the "green number" corresponds to the number of agents required to halt it.

A previous study modeled terrorist cells as partially ordered sets (a special kind of DAG), which are often used in mathematics to analyze an ordering, sequencing, or arrangement of distinct objects. In such a system, terrorist plans are formulated by nodes at the top of the hierarchy, which represent the leaders or maximal nodes of the set. The plans are transmitted down to the nodes at the bottom: these represent foot soldiers in a terror network or minimal nodes in the set who would be presumed to carry out these plans. The assumption is that one messenger is sufficient for reception and execution of the plan. Thus, if the partially ordered set represents a courier network for a terrorist organization, the intention would be to block all routes from the maximal node to the minimal nodes by capturing or killing a subset of agents.

In this paper, the authors utilize the similarities in the previous terrorist cell model to Seepage, where greens try to prevent the sludge from moving to the sinks by blocking nodes. A number of different winning strategies employed by both players are explored when played on a DAG. The seepage and green number for disrupting a given hierarchical social network are analyzed.

The primary difference from the previous study's model is that the Seepage model is dynamic: greens can move and choose new sets of nodes over time. The authors determine that Seepage is a more realistic model of counterterrorism, as the agents do not necessarily act all at once, but over time.

The analysis is made in two types of terrorist network structures, as Pralat explains, "We consider two extreme profiles: one where the network is regular, where every agent has about the same number of connections. The second profile is power law, where some agents have many connections, but most have very few." This is analyzed by considering the total degree distribution of nodes in the DAG. In regular DAGs, each level of the DAG would have nodes with about the same out-degree (number of outgoing edges emanating from a node), while power law DAGs would have many more low-degree nodes and a few with high degrees.

Mathematical analysis allows the authors to determine what point in a network would be most effective for disrupting messages. "Our mathematical results reinforce the view that intercepting the information or message in a hierarchical social network following a power law is more difficult close to levels near the source. For regular networks, it does not matter as much where the message is disrupted," says Pralat. "Future work could look at more complex profiles of networks, along with developing effective algorithms for disrupting the flow of information in a DAG using our game-theoretic approach."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/Adpbt4Zmc_4/130516142656.htm

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New craters abound: Mars camera reveals hundreds of impacts each year

May 15, 2013 ? Taking before and after pictures of Martian terrain, researchers of the UA-led HiRISE imaging experiment have identified almost 250 fresh impact craters on the Red Planet. The results suggest Mars gets pummeled by space rocks less frequently than previously thought, as scientists relied on cratering rates of the moon for their estimates.

Scientists using images from NASA's Mars Reconnaissance Orbiter, or MRO, have estimated that the planet is bombarded by more than 200 small asteroids or bits of comets per year forming craters at least 12.8 feet (3.9 meters) across.

Researchers have identified 248 new impact sites on parts of the Martian surface in the past decade, using images from the spacecraft to determine when the craters appeared. The 200-per-year planetwide estimate is a calculation based on the number found in a systematic survey of a portion of the planet.

The University of Arizona's High Resolution Imaging Science Experiment, or HiRISE camera, took pictures of the fresh craters at sites where before and after images had been taken. This combination provided a new way to make direct measurements of the impact rate on Mars and will lead to better age estimates of recent features on Mars, some of which may have been the result of climate change.

"It's exciting to find these new craters right after they form," said Ingrid Daubar of the UA, lead author of the paper published online this month by the journal Icarus. "It reminds you Mars is an active planet, and we can study processes that are happening today."

These asteroids or comet fragments typically are no more than 3 to 6 feet (1 to 2 meters) in diameter. Space rocks too small to reach the ground on Earth cause craters on Mars because the Red Planet has a much thinner atmosphere.

HiRISE targeted places where dark spots had appeared during the time between images taken by the spacecraft's Context Camera, or CTX, or cameras on other orbiters. The new estimate of cratering rate is based on a portion of the 248 new craters detected. If comes from a systematic check of a dusty fraction of the planet with CTX since late 2006.

The impacts disturb the dust, creating noticeable blast zones. In this part of the research, 44 fresh impact sites were identified.

The meteor over Chelyabinsk, Russia, in February was about 10 times bigger than the objects that dug the fresh Martian craters.

Estimates of the rate at which new craters appear serve as scientists' best yardstick for estimating the ages of exposed landscape surfaces on Mars and other worlds.

Daubar and co-authors calculated a rate for how frequently new craters at least 12.8 feet (3.9 meters) in diameter are excavated. The rate is equivalent to an average of one each year on each area of the Martian surface roughly the size of the U.S. state of Texas. Earlier estimates pegged the cratering rate at three to 10 times more craters per year. They were based on studies of craters on the moon and the ages of lunar rocks collected during NASA's Apollo missions in the late 1960s and early 1970s.

"Mars now has the best-known current rate of cratering in the solar system," said UA's HiRISE Principal Investigator Alfred McEwen, a co-author on the paper.

MRO has been examining Mars with six instruments since 2006. Daubar is an imaging targeting specialist who has been on the HiRISE uplink operation s team from the very beginning. She is also a graduate student in the UA's department of planetary science and plans on graduating with her doctorate in spring 2014.

"There are five of us who help plan the images that HiRISE will take over a two-week cycle," she explained. "We work with science team members across the world to understand their science goals, help select the image targets and compile the commands for the spacecraft and the camera."

"The longevity of this mission is providing wonderful opportunities for investigating changes on Mars," said MRO Deputy Project Scientist Leslie Tamppari of NASA's Jet Propulsion Laboratory in Pasadena, Calif.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/mFjMtBuwz-8/130515165025.htm

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First prospective trial shows molecular profiling timely for tailoring therapy

May 15, 2013 ? A clinical trial has shown that patients, and their physicians, are eager to jump into next-era cancer care -- analysis of an individual's tumor to find and target genetic mutations that drive the cancer. Results of the study, CUSTOM, are being presented at the 2013 annual meeting of the American Society of Clinical Oncology years before investigators thought they would be ready.

CUSTOM is the first completed prospective clinical trial that used genetic analysis alone to assign cancer treatment for patients with one of three different cancers.

"We expected it would take five years to enroll 600 patients into CUSTOM. But in less than two years, 668 patients were recruited," says the study's lead investigator, Giuseppe Giaccone, MD, PhD, associate director for clinical research at Georgetown Lombardi Comprehensive Cancer Center.

"This was a surprise to all of us, especially since patients with advanced cancer who already had biopsies needed to undergo an additional biopsy for the study. But we found patients and their doctors are quite interested in this type of personalized medicine. They know that the molecular profile of the tumor is important," says Giaconne, who is also director of clinical research for the MedStar Georgetown Cancer Network, a regional oncology affiliation between MedStar Health and Georgetown Lombardi.

CUSTOM has proved to be a model for more efficient clinical trials, he adds. It showed that patients want to participate in this kind of research, and that it is feasible to do extensive genetic testing on a tumor biopsy in a timely manner -- in this case, taking only two weeks to complete. It also demonstrated that it is safe to take new biopsy from patients with advanced cancer to provide the tissue needed for the analysis.

One of the other endpoints of the study, however, was not achieved. Researchers discovered that, in many cases, they did not have enough patients with rare cancer mutations to provide an accurate statistical analysis of response to novel drugs, says Giaccone.

Giaccone led the clinical trial while at the National Cancer Institute where he was the Chief of the Medical Oncology Branch, before he joined Georgetown in January. Researchers at Oregon Health & Science University also participated.

CUSTOM enrolled patients diagnosed with advanced stage non-small cell lung cancer, small cell lung cancer or thymic cancer. Researchers used next-generation sequencing, which was novel at the time, to look at almost 200 genes. From this, patients were assigned to different treatment groups based on genetic mutations or amplification.

Results from the largest group -- patients with non-small cell lung cancer -- had either an EGFR or a KRAS mutation, and results showed that those with EGFR mutations had a very high response to the drug erlotinib. "This is nothing new; we essentially confirmed what was already known," Giaccone says. But they also discovered that patients with KRAS mutations did not benefit from the single agent investigational drug selumetinib, which is being studied for use in a number of cancers, including non-small cell lung cancer.

Results for the patients with small cell lung or thymic cancers were inconclusive, primarily because the investigated mutations were rare -- not enough patients had specific mutations to adequately test response to therapy. "When we started the study, we didn't know how frequently the mutations occurred," Giaccone says. "Now we know that many mutations represent only 1 to 2 percent of patients and to do this right, you need to screen thousands of patients. That is only possible with a global study that involves, potentially, hundreds of institutions.

"The CUSTOM trial demonstrates both the feasibility of the approach for common mutations -- that it is possible to have a real-time genetic analysis that guides treatment -- as well as the difficulty of studying treatment for rare mutations," he says.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/aoeMV8xq6FU/130515203044.htm

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90% Beyond The Hills

All Critics (80) | Top Critics (30) | Fresh (72) | Rotten (8)

The final shot, with windshield wipers struggling to clean away a torrent of muddy water, suggests that no human agency is great enough to handle this world's misery.

"Beyond the Hills" seethes with astonishment and rage at a broken society marooned between the 21st century and the 16th.

It is a haunting movie, dealing with superstitions, possession, even exorcism, one in which Mungiu poses no easy answers, because there are none to be found.

If you long for the bleak intelligence of an Ingmar Bergman film, where humankind is deeply flawed and God is indifferently silent and the landscape is cloaked in perpetual winter, then Beyond the Hills promises to be your cup of despair.

There are no easy villains or heroes in this sad and slow but forcefully told tale, which exhibits the same humanity Mungiu brought to 4 Months, 3 Weeks and 2 Days, his abortion drama that won the 2007 Palme d'Or.

A film that asks its viewer to consider the nature of good and evil, love and trust - and trust that turns into something like blind faith.

You'd swear Mungiu has inherited the spirit of Ingmar Bergman. All that's missing is the stark black-and-white photography.

Beyond the Hills' undercurrents prove more interesting than its storyline or characters.

Strikingly shot and punishingly long ...

(Writer-director Christian) Mungiu balances his film's more disturbing content with peaceful shots of the idyllic, surrounding countryside and of intimacy between the two women while slowly building to an inevitable conclusion.

When the ill and unstable Alina returns to the monastery, just so she can be with her beloved, Beyond the Hills becomes a species of those exorcism movies that audiences gorge on, only done with a realism and ambiguity usually missing from the genre.

What makes this movie unique is that it holds literally everyone in the film accountable for the unfortunate goings on.

It's an exorcism movie for everyone who thought, after Mungiu's gruelling abortion buddy-movie 4 Months, 3 Weeks and 2 Days, that this guy should do an exorcism movie

It's an enigmatic and austere film from a region where political, sexual and religious repression are as stifling as the sooty air.

Mungui's rigorous approach to filmmaking isn't a ton of fun to watch, but his ideas stick with you.

It delivers an emotional punch, in what its director has called a story about the sin of indifference.

Such is the rigorous and high-minded nature of Romanian cinema that even a real-life exorcism story can inspire something loftier than a horror movie.

Heartbreak at a Romanian convent

...Cristian Mungiu has taken a real life event...to consider deeply human philosophies such as freedom vs. discipline, love vs. security, the choices facing those without financial recourse and the hypocrisies of organized religions.

I found it riveting to watch and fascinating to think about afterwards.

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Source: http://www.rottentomatoes.com/m/beyond_the_hills_2012/

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বৃহস্পতিবার, ১৬ মে, ২০১৩

PayPal Targets Small Businesses in Offline Rollout - Digits - WSJ

EBay Inc. has been pushing for acceptance of PayPal in some of the largest U.S. retail stores, like Home Depot. Now it is targeting the smallest businesses.

PayPal on Tuesday unveiled a new program to compel small merchants to throw away their cash registers in favor of iPads, card swipers and modern printers.

PayPal President David Marcus said the company will in exchange cover the merchants? credit card bills for the remainder of the year. A typical transformation from to the more modern system costs between $1,200 and $1,500, he said.

?We are accelerating the inevitable acceptance of payment systems like PayPal,? Mr. Marcus said in an interview.

Merchants won?t be required to use PayPal for all their transactions, though the program applies only to those switching to a system with PayPal already integrated, such as Erply, Leaf and Vend.

To qualify, companies have to be primarily using more old-fashioned systems like a cash register. PayPal may send out employees to retrieve the register and verify the system upgrade, said Mr. Marcus.

Of course, there will be limits on PayPal?s payout and the size of the business that qualify, though Mr. Marcus said those details are forthcoming. ?It?s not limitless, otherwise there will be companies that try to abuse it,? he said.

PayPal has been working to build its business in the bricks-and-mortar world to complement its online payments, particularly on eBay.com.

Last year it announced a partnership with Discover that will take PayPal to most stores where Discover is accepted.

Source: http://blogs.wsj.com/digits/2013/05/14/paypal-targets-small-businesses-in-offline-rollout/

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